Effect of Thyroxine and 2,4-Dinitrophenol on the Rate of Utilization of Glucose


IT has long been recognized that 2,4-dinitrophenol increases oxidative metabolism. The increase of oxygen consumption after the addition of 2,4-dinitrophenol (DNP) is explained as being a result of dissociation between oxidative and phosphorylative processes. Similarly, thyroxine accelerates oxidation by uncoupling an oxidative phosphorylation. But DNP does not prevent the phenomena of hypothyroidism other than basal metabolism1, and fails to change lipid metabolism1,2 and nitrogen excretion, the effects of which are known to follow thyroxine administration1. Therefore, it was interesting to compare the effects of these agents on carbohydrate metabolism.

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MACHO, L. Effect of Thyroxine and 2,4-Dinitrophenol on the Rate of Utilization of Glucose. Nature 191, 604 (1961). https://doi.org/10.1038/191604a0

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