Blockage of Transformation of Tryptophan to Nicotinic Acid by Experimental Hepatitis in Mice

Abstract

THE existence of biochemical lesions in the complicated path from amino-acid to vitamin in man, and in experimental animals suffering from various diseases, has been identified by a number of authors analysing urinary metabolites of tryptophan by means of paper and column chromatography1–6. These analyses have shown an accumulation in the urine of metabolites proximal to the lesion.

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References

  1. 1

    Altman, K. I., and Miller, G., Nature, 172, 868 (1953).

  2. 2

    Boyland, E., and Watson, G., Nature, 177, 837 (1956).

  3. 3

    Musajo, L., Benassi, C. A., and Parpaiola, A., Clin. Chim. Acta, 1, 229 (1956).

  4. 4

    Quagliariello, E., Auricchio, S., Casale, M., and Tancredi, F., Boll. Soc. Ital. Biol. Sper., 34, 1918 (1958).

  5. 5

    Auricchio, S., Quagliariello, E., Rubino, A., and Vecchione, L., Ann. Paediat., 194, 129 (1960).

  6. 6

    Quagliariello, E., Auricchio, S., Saccone, C., and Sganga, W., Boll. Soc. Ital. Biol. Sper., 35, 343 (1960).

  7. 7

    Dalgliesh, C. E., J. Clin. Path., 8, 73 (1955).

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PIAZZA, M., TANCREDI, F. & QUAGLIARIELLO, E. Blockage of Transformation of Tryptophan to Nicotinic Acid by Experimental Hepatitis in Mice. Nature 191, 601 (1961). https://doi.org/10.1038/191601a0

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