Abstract
THE existence of biochemical lesions in the complicated path from amino-acid to vitamin in man, and in experimental animals suffering from various diseases, has been identified by a number of authors analysing urinary metabolites of tryptophan by means of paper and column chromatography1–6. These analyses have shown an accumulation in the urine of metabolites proximal to the lesion.
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PIAZZA, M., TANCREDI, F. & QUAGLIARIELLO, E. Blockage of Transformation of Tryptophan to Nicotinic Acid by Experimental Hepatitis in Mice. Nature 191, 601 (1961). https://doi.org/10.1038/191601a0
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DOI: https://doi.org/10.1038/191601a0
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