Effect of Pituitary Growth Hormone on Cholesterogenesis


IT has been reported earlier that injections of anterior pituitary growth hormone into adult female rats cause a decrease in the rate of synthesis of fatty acid and an increase in the rate of cholesterogenesis in the liver1. Inverse relationships of this type have also been described as occurring in diabetic rats2 and in normal rats injected with thyroxine3. These results were obtained using labelled acetate as substrate. The availability of labelled mevalonic acid now permits some dissection of the pathway involved.

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GREENBAUM, A., LEAL, R. Effect of Pituitary Growth Hormone on Cholesterogenesis. Nature 191, 600–601 (1961). https://doi.org/10.1038/191600a0

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