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Quantitative Determination of Metadrenaline and Normetadrenaline in Normal Human Urine

Nature volume 191, pages 599–600 (1961)Cite this article

Abstract

SEVERAL authors have performed investigations on metadrenaline and normetadrenaline, metabolites of catecholamines, since their discovery by Axelrod1. Previous work, however, dealt mostly with the urine of rats2, in which relatively large amounts of the metabolites are excreted, or the isotope tracer of authentic methoxycatecholamines3 which can be detected easily by their radioactivity. Metadrenaline and normetadrenaline in normal human urine have never been determined quantitatively, because of their very low concentrations. This communication concerns the method of determination of methoxycatecholamines in urine of normal human beings.

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References

  1. Goodall, M., Pharmacol. Rev., 11 (Part 2), 416 (1959).

    CAS  PubMed  Google Scholar 

  2. Bernheimer, H., Ehringer, H., Heistracher, P., and Kraupp, O., Biochem. Z., 332, 416 (1960).

    CAS  PubMed  Google Scholar 

  3. Axelrod, J., Science, 126, 400 (1957).

    Article  ADS  CAS  Google Scholar 

  4. Goodall, M., Kirshner, N., and Rosen, L., J. Clin. Invest., 38, 707 (1959).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan

    KAORU YOSHINAGA, CHUICHI ITOH, NOZOMU ISHIDA, TATSUO SATO & YASUO WADA

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  1. KAORU YOSHINAGA
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  2. CHUICHI ITOH
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  3. NOZOMU ISHIDA
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  4. TATSUO SATO
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  5. YASUO WADA
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YOSHINAGA, K., ITOH, C., ISHIDA, N. et al. Quantitative Determination of Metadrenaline and Normetadrenaline in Normal Human Urine. Nature 191, 599–600 (1961). https://doi.org/10.1038/191599a0

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