Letter | Published:

Specific Inhibition of Anti-D Antibody by Colominic Acid

Naturevolume 191page511 (1961) | Download Citation



IN ref. 1 it is reported that certain nucleotides specifically inhibited anti-Rh antibodies, and in ref. 2 that there is specific inhibition by certain monosaccharides and substances such as rutinose and streptomycin. Although some differences in the effect of these substances on anti-C, anti-D and anti-E were observed by both groups of workers, in general a substance that inhibited one auti-Rh serum also inhibited the others. More recently, Dodd, Bigley and Geyer3 have reported that N-acetyl neuraminic acid and certain related compounds inhibit anti-D but not anti-C or anti-E ; this is a greater degree of specificity than that claimed in the first two reports.

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  1. 1

    Hackel, E., Smolker, R. E., and Fenske, S. A., Vox Sang., 3, 402 (1958).

  2. 2

    Boyd, W. C., McMaster, M. H., and Waszczenko-Zacharczenko, E., Nature, 184, 989 (1959).

  3. 3

    Dodd, M. C., Bigley, N. J., and Geyer, V. B., Science, 132, 1398 (1960).

  4. 4

    Barry, G. T., and Goebel, W. F., Nature, 179, 206 (1957).

  5. 5

    Barry, G. T., J. Exp. Med., 107, 507 (1958).

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  1. Department of Immunochemistry, Boston University School of Medicine, Boston, 18, Massachusetts

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