Letter | Published:

Direct Relationship of Phosphorylase and Mitochondrial α-Glycerophosphate Dehydrogenase Activity in Skeletal Muscle

Naturevolume 191page504 (1961) | Download Citation

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Abstract

PREVIOUS work1 showed that in mammalian and avian muscle fibres there was a reciprocal relationship between phosphorylase and the oxidative enzymes, as shown by histochemical techniques. Two groups of fibres were described. In the histologically larger group, there was high phosphorylase activity and low activity of oxidative enzymes. (These included succinate, lactate, malate, isocitrate, β-hydroxy-butyrate, alcohol and glutamate dehydrogenases, and also the DPN-linked α-glycerophosphate dehydrogenase.) In the group of histologically smaller fibres the converse activities were present.

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References

  1. 1

    Dubowitz, V., and Pearse, A. G. E., Nature, 185, 701 (1960); Histochemie, 2, 105 (1960).

  2. 2

    Wattenberg, L. W., and Leong, J. L., J. Histochem. Cytochem., 8, 296 (1960). Hess, R., and Pearse, A. G. E., Nature (in the press).

  3. 3

    Bücher, Th.,and Klingenberg, M., Angew. Chem., 70, 552 (1958). Zebe, E., Delbrück, A., and Bücher, Th., Biochem. Z., 331, 254 (1959).

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  1. Postgraduate Medical School, London, W.12

    • A. G. E. PEARSE

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https://doi.org/10.1038/191504a0

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