Letter | Published:

Direct Relationship of Phosphorylase and Mitochondrial α-Glycerophosphate Dehydrogenase Activity in Skeletal Muscle

Naturevolume 191page504 (1961) | Download Citation



PREVIOUS work1 showed that in mammalian and avian muscle fibres there was a reciprocal relationship between phosphorylase and the oxidative enzymes, as shown by histochemical techniques. Two groups of fibres were described. In the histologically larger group, there was high phosphorylase activity and low activity of oxidative enzymes. (These included succinate, lactate, malate, isocitrate, β-hydroxy-butyrate, alcohol and glutamate dehydrogenases, and also the DPN-linked α-glycerophosphate dehydrogenase.) In the group of histologically smaller fibres the converse activities were present.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Dubowitz, V., and Pearse, A. G. E., Nature, 185, 701 (1960); Histochemie, 2, 105 (1960).

  2. 2

    Wattenberg, L. W., and Leong, J. L., J. Histochem. Cytochem., 8, 296 (1960). Hess, R., and Pearse, A. G. E., Nature (in the press).

  3. 3

    Bücher, Th.,and Klingenberg, M., Angew. Chem., 70, 552 (1958). Zebe, E., Delbrück, A., and Bücher, Th., Biochem. Z., 331, 254 (1959).

Download references

Author information


  1. Postgraduate Medical School, London, W.12

    • A. G. E. PEARSE


  1. Search for A. G. E. PEARSE in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.