Letter | Published:

Effects of Injections of Some Intermediary Metabolites on the ‘Insulin Response’ of Normal Rabbits

Naturevolume 191pages491492 (1961) | Download Citation

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  • An Erratum to this article was published on 19 August 1961

Abstract

CONTINUED daily injections of β-hydroxy butyrate in gradually increasing doses has been found to increase initially the insulin content of the pancreases of guinea pigs and then bring about a gradual decrease of active insulin/gm. of pancreas tissue1. Similar experiments by Schwartz et al. 2 have recently confirmed these findings in both guinea pigs and albino-rats. The present communication indicates the effects of some members of the trichloroacetic acid cycle, compared to β-hydroxy butyrate, on the insulin response of normal rabbits.

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References

  1. 1

    Brahmachari, H. D., and Mahendra Kumar, Nature, 183, 51 (1959).

  2. 2

    Schwartz et al., Nature, 185, 771 (1960).

  3. 3

    Marks, League of Nations Rep. Insulin Standardization, C.H. 396 (1928).

  4. 4

    Folin, and Malmros, J. Biol. Chem., 83, 115 (1929).

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Author information

Affiliations

  1. Biochemistry Laboratory, Birla College, Pilani, Rajasthan

    • H. D. BRAHMACHARI
    •  & G. RAGHUPATHY SARMA

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https://doi.org/10.1038/191491a0

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