Letter | Published:

Activation of Amino-Acids in Micro-Organisms which produce Antibiotics

Naturevolume 191page411 (1961) | Download Citation

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Abstract

IT seems well established that the first steps in the biosynthesis of proteins are the activation of amino-acids in the presence of adenosine triphosphate (ATP) and the transfer of the activated amino-acids to a soluble fraction of ribonucleic acid (RNA)1. Such reactions are also involved in the biosynthesis of some peptides, for example, the condensation of glutamyl-cysteine with glycine to give glutathione2. Enzymes activating almost all the naturally occurring L-amino-acids have been isolated from animal, plant, and microbial sources. Only one enzyme active on a D-amino acid, D-alanine, has been demonstrated in cells of Lactobacillus arabinosus and other Lacto-bacillaceae3.

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References

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    Lipmann, F., et al., J. Cell. Comp. Physiol., 54, Supp. 1, 75 (1959). Hoagland, M. B., Fourth Int. Congr. Biochem., Symp. 8, 199 (1960). Novelli, G. D., Ann. Rev. Microbiol., 14, 65 (1960).

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    Bates, H. M., and Lipmann, F., J. Biol. Chem., 235, PC 22 (1960).

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    Baddiley, J., and Nehaus, F. C., Biochem. J., 75, 579 (1960).

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    DeMoss, J. A., and Novelli, G. D., Biochim. Biophys. Acta, 22, 49 (1956).

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    Ito, E., and Strominger, J. L., J. Biol. Chem., 235, PC 5, PC 7 (1960).

  6. 6

    Di Girolamo, M., Ciferri, O., and Bendicenti Di Girolamo, A. (unpublished results).

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Affiliations

  1. Istituto di Genetica, Università di Pavia, Pavia

    • O. CIFERRI
    • , M. DI GIROLAMO
    •  & A. BENDICENTI DI GIROLAMO

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https://doi.org/10.1038/191411a0

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