Letter | Published:

Effect of Enzyme Injections on Mitosis in Regenerating Liver

Naturevolume 191pages400401 (1961) | Download Citation

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Abstract

THE addition of deoxyribonuclease to tissue-culture media affected mitosis in tissue cultures1,2. In mice bearing Ehrlich ascites tumours, injections of the enzyme decreased the incidence of mitoses in the tumour cells and increased the survival-time of the animals3. Similarly, injections of xanthine oxidase and ribonuclease affected the rate of tumour growth and the survival time4–6.

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References

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    Chevremont, M., Chevremont-Comhaire, S., and Backeland, E., C.R. Acad. Sci., Paris, 247, 2197 (1958).

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    de Lamirande, G., Proc. Amer. Assoc. Cancer Res., 3, 105 (1960).

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    Haddow, A., et al., Brit. Empire Cancer Campaign Ann. Rep., 31, 35 (1953); 32, 50 (1954).

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    Haddow, A., de Lamirande, G., Bergel, F., Bray, R. C., and Gilbert, D. A., Nature, 182, 1144 (1958).

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    Ledoux, L., Nature, 175, 258 (1955) ; 176, 36 (1955).

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    Higgins, G. M., and Anderson, R. M., Arch. Path., 12, 186 (1931).

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    Jaffe, J., Anat. Rec., 120, 953 (1954).

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    de Lamirande, G., Allard, C., and Cantero, A., Cancer Res., 18, 952 (1958).

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Author notes

  1. GASTON DE LAMIRANDE: Research Associate of the National Cancer Institute of Canada.

Affiliations

  1. Montreal Cancer Institute, Research Laboratories, Notre Dame Hospital and University of Montreal, Montreal

    • GASTON DE LAMIRANDE

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https://doi.org/10.1038/191400b0

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