Letter | Published:

Effect of Enzyme Injections on Mitosis in Regenerating Liver

Naturevolume 191pages400401 (1961) | Download Citation



THE addition of deoxyribonuclease to tissue-culture media affected mitosis in tissue cultures1,2. In mice bearing Ehrlich ascites tumours, injections of the enzyme decreased the incidence of mitoses in the tumour cells and increased the survival-time of the animals3. Similarly, injections of xanthine oxidase and ribonuclease affected the rate of tumour growth and the survival time4–6.

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    Haddow, A., et al., Brit. Empire Cancer Campaign Ann. Rep., 31, 35 (1953); 32, 50 (1954).

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    Haddow, A., de Lamirande, G., Bergel, F., Bray, R. C., and Gilbert, D. A., Nature, 182, 1144 (1958).

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  1. GASTON DE LAMIRANDE: Research Associate of the National Cancer Institute of Canada.


  1. Montreal Cancer Institute, Research Laboratories, Notre Dame Hospital and University of Montreal, Montreal



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