Letter | Published:

Selective Uptake of Specifically Bound Cobalt-58 Vitamin B12 by Human and Mouse Tumour Cells

Naturevolume 191pages393395 (1961) | Download Citation



MANY body fluids have been reported to contain substances that combine with vitamin B12. However, research concerning the role of these substances in the absorption of vitamin B12 by animal cells has been confined mainly to work involving intrinsic factor preparations or normal human gastric juice. A large amount of evidence has led to general acceptance that vitamin B12 bound to intrinsic factor is taken up by intestinal mucosa cells to a greater extent than unbound vitamin B12 (ref. 1). Intrinsic factor also has been shown to promote uptake of vitamin B12 by rat liver slices2,3 and liver homogenates4. The latter process apparently is not influenced by changes of temperature, and it is not affected by metabolic inhibitors such as 2,4-dinitrophenol3.

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    Castle, W. B., Gastroenterology, 37, 377 (1959).

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    Miller, O. N., Raney, J. L., and Hunter, F. M., Fed. Proc., 16, 339 (1957).

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    Herbert, V., Amer. J. Clin. Nutr., 7, 433 (1959).

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    Herbert, V., Castro, Z., and Wasserman, L. R., Proc. Soc. Exp. Biol. Med., 104, 160 (1960).

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    Callender, S. T., and Lajtha, L. C., Blood, 6, 1234 (1951).

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  1. Hæmatology Service, Dept. of Medicine, The Royal Victoria Hospital and the McGill University Clinic

  2. the McGill–Montreal General Hospital Research Institute, Montreal



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