Letter | Published:

Effect of Polyamino Carboxylic Acids on Catalase

Naturevolume 191page385 (1961) | Download Citation



CATALASES are known to be inactivated by the formation of compounds with cyanide1, azide and hydroxylamine2, so we thought it probable that the iron of the enzyme could be complexed with chelating agents, the effect being also to inactivate the enzyme. The chelating agents used were ethylenediamine tetraacetic acid (EDTA), cyclohexanediamine tetraacetic acid (CDTA), diethylenetriamine pentaacetic acid (DTPA) and NN′ethylenebis (2{o-hydroxyphenyl}) glycine (EHPG). The rate of decomposition of hydrogen peroxide by bovine-liver catalase in the presence of each of the above chelating agents was followed by a rapid titration method.

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  1. 1

    Chance, B., J. Biol. Chem., 179, 1299 (1949).

  2. 2

    Foulkes, E. C., and Lemberg, R., Enzymologia, 13, 302 (1949).

  3. 3

    Chance, B., J. Biol. Chem., 179, 1299 (1949).

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  1. Department of Pure and Applied Chemistry, Royal College of Advanced Technology, Salford, 5

    •  & J. G. COOPER


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