Letter | Published:

Leukæmia in the AkR Mouse after X-Irradiation in utero

Naturevolume 191pages291292 (1961) | Download Citation



IT is known that the incidence of lymphoid leukæmia in mice is influenced by X-irradiation of the adult1. In strains where the spontaneous incidence of the disease is low, it is increased ; but it may be decreased when the incidence is already high2. In the high-leukæmia strain AkR mouse, it has been shown that, after doses of X-rays of between 50 and 500 r. to the new-born animal, there is a reduction of the usually high incidence of leukæmia, slightly among females but more markedly among males even at the lowest doses3.

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    Krebs, C., Rask-Nielsen, H. C., and Wagner, A., Acta Radiol., Supp. 10, 1 (1930). Furth, J., and Furth, O. B., Amer. J. Cancer, 28, 54 (1936).

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    Kirschbaum, A., and Mixer, H. W., J. Lab. and Clin. Med., 32, 720 (1947).

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    Reverdy, J., Rudali, G., Duplan, J. F., and Latarjet, R., Le Sang, 29, 796 (1958).

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    Stewart, A., Webb, J., Giles, D., and Hewitt, D., Lancet, ii, 447 (1956). Stewart, A., Webb, J., and Hewitt, D., Brit. Med. J., i, 1496 (1958). Court Brown, W. M., Doll, R., and Bradford Hill, A., ibid., ii, 1539 (1960).

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  1. Radiobiology Department, Christie Hospital and Holt Radium Institute, Manchester, 20



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