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Urea Synthesis in the Living Rat Brain

Naturevolume 191page288 (1961) | Download Citation



IN previous communications from this laboratory, the synthesis of urea-14C from arginine-14C was reported to occur in the living rat brain1,2. In these experiments only the rat brains were analysed for their radioactive urea content, and the objection was raised that perhaps these levels did not indicate endogenous brain urea synthesis, but were merely a reflexion of blood 14C-urea levels, especially since it is known that urea readily diffuses across the blood brain barrier. Experiments were therefore designed to show that the brain 14C-urea levels were independent of blood 14C-urea levels and that the brain had the capacity to synthesize urea from arginine. This communication describes such experiments.

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    Sporn, M. B., Dingman, W., Defalco, A., and Davies, R. K., J. Neurochem., 5, 62 (1959).

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    Sporn, M. B., Dingman, W., Defalco, A., and Davies, R. K., Nature, 183, 1520 (1959).

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    Toennies, G., and Kolb, J. J., J. Anal. Chem., 23, 823 (1951).

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    Berry, H. K., Sutton, H. E., Cain, L., and Berry, J. S., Univer. of Texas Publication 5109, 22 (1951).

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    Ratner, et al., Archiv. Biochem. and Biophys., 91, 280 (1960).

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  1. R. K. DAVIES, A. J. DEFALCO, D. SHANDER and A. KOPELMAN: Scottish Rite Summer Medical Student Research Fellows.


  1. Departments of Psychiatry and Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York

    • R. K. DAVIES
    • , A. J. DEFALCO
    • , D. SHANDER
    • , A. KOPELMAN
    •  & J. KIYASU


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