Abstract
THE identification of the keto-acid 2,4-dinitrophenylhydrazones is greatly facilitated by conversion to their respective amino-acids. The most commonly employed procedure is that first noted by Emil Fischer1 and modified for application to organic systems by Towers et al.2. This involves low-pressure hydrogenolysis over a platinum catalyst, followed by paper chromatography of the amino-acids produced. The yields of the respective amino-acids vary between 30 and 98 per cent, and in general the conversion is free from side-reactions.
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References
Fischer, E., and Groh, R., Ann., 383, 363 (1911).
Towers, G. H. N., Thompson, J. F., and Steward, F. C., J. Amer. Chem. Soc., 76, 2392 (1954).
Menkes, J. H., A.M.A., J. Dis. Child., 99, 500 (1960).
Menkes, J. H., and Jervis, G. A., Pediatrics (in the press).
Smith, H. A., Alderman, D. M., and Nadig, F. W., J. Amer. Chem. Soc., 67, 272 (1945).
Waser, E., and Brauchli, E., Helv. Chim. Acta, 7, 740 (1924).
Levin, R. H., and Pendergrass, J. H., J. Amer. Chem. Soc., 69, 2436 (1947).
Smith, H. A., Catalysis, edit. by Emmett, P. H., 5, 175 (New York, 1957).
Edson, N. L., J. Soc. Chem. Indust., 53, 138 T (1934).
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MENKES, J. Side-Reactions during Hydrogenolysis of 2,4-Dinitrophenylhydrazones of Aromatic Keto-Acids. Nature 191, 285–286 (1961). https://doi.org/10.1038/191285a0
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DOI: https://doi.org/10.1038/191285a0
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