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Low-Angle Light Scattering and the Molecular Weight of Deoxyribonucleic Acid

Naturevolume 191pages280281 (1961) | Download Citation



IT has been known for some time that the molecular weights obtained for deoxyribonucleic acid (DNA) by present-day techniques in light-scattering may be in error. This situation is not the result of theoretical barriers, but rather, the very considerable experimental problems to be solved in making reliable measurements of scattering below angles of 25°. Accordingly, considerable effort has been made to assess by indirect methods the validity of light-scattering molecular weights determined by extrapolation of data which extend to no lower than 25°. Doty, Geiduschek and Holtzer and more recently Butler et al. have given1–3 detailed critical discussions of the nature of the indirect evidence and the remaining ambiguities.

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  1. 1

    Doty, P., J. Cell Comp. Physiol., 49, 27 (1957).

  2. 2

    Geiduschek, E. P., and Holtzer, A., in Advances in Biological and Medical Physics, 6, 431 (Academic Press, New York, 1958).

  3. 3

    Butler, J. A. V., Laurence, D. J. R., Robins, A. B., and Shooter, K. V., Proc. Roy. Soc., A, 250, 1 (1959).

  4. 4

    Signer, R., and Schwander, H., Helv. Chim. Acta, 33, 1522 (1950).

  5. 5

    Bjorklund, R., and Katz, S., J. Amer. Chem. Soc., 78, 2122 (1956).

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  1. Department of Biophysics, School of Medicine, University of Buffalo, Buffalo, New York



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