Letter | Published:

Distribution of Piperidine in the Brain and its Possible Significance in Behaviour

Naturevolume 191pages201202 (1961) | Download Citation

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Abstract

RECENT work on the use of piperidine for treating psychiatric disorders1 has prompted an extensive programme here to investigate the mechanism of action of this simple chemical. The basis for using piperidine as a psychotherapeutic agent originally developed from the discovery that the agent antagonized the central actions of N-methyl 3-piperidyl-glycolate and other piperidinoglycolates possessing psychotomimetic properties2. These findings were particularly significant because piperidine has been found in human urine3 and mammalian brains4. Piperidine might be an endogenous agent serving some normal function in the regulation of behaviour; that is, perhaps the amine is an endogenous psychotropic agent.

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References

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    Tasher, D. C., Abood, L. G., Gibbs, F. A., and Gibbs, E., J. Neuropsychiat., 1, 266 (1960).

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    Abood, L. G., Ostfeld, A., and Biel, J. H., Arch. int. de Pharmacodyn., 120, 186 (1959).

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    Von Euler, U. S., Acta Pharmacol., 1, 29 (1945).

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    Honegger, C. G., and Honegger, R., Nature, 185, 530 (1960).

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    Abood, L. G., and Rinaldi, F., Psychopharmacologia, 1, 117 (1959).

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    Dawson, R. F., Amer. Scientist, 48, 321 (1960).

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Author information

Affiliations

  1. Departments of Psychiatry and Biochemistry, University of Illinois College of Medicine, and Abbott Laboratories, North Chicago

    • L. G. ABOOD
    • , F. RINALDI
    •  & VIRGINIA EAGLETON

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https://doi.org/10.1038/191201a0

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