Letter | Published:

Inactivation and Reactivation of Chymotrypsin

Naturevolume 191page178 (1961) | Download Citation

Subjects

Abstract

IN previous work on the immediate effects of acylation of trypsin it was shown1 that the enzyme can be obtained in a fully inactive form by acylation with various anhydrides at pH 8–9, and that partial instantaneous reactivation can be effected by treatment with alkaline hydroxylamine2.

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References

  1. 1

    Antony, Teresa Therattil, Bier, M., and Nord, F. F., Arch. Biochem. Biophys., 87, 150 (1960).

  2. 2

    Antony, Teresa Therattil, Bier, M., and Nord, F. F., Nature, 189, 809 (1961).

  3. 3

    Balls, A. K., and Wood, H. N., J. Biol. Chem., 219, 245 (1956).

  4. 4

    Dixon, G. H., and Neurath, H., J. Biol. Chem., 225, 1049 (1957).

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Author information

Affiliations

  1. Laboratory of Organic Chemistry and Enzymology, Fordham University, New York, 58

    • T. THERATTIL ANTONY
  2. Department of Chemistry, University of Delhi

    • T. THERATTIL ANTONY

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DOI

https://doi.org/10.1038/191178a0

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