Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mechanism of Synthesis of Adenine from Hydrogen Cyanide under Possible Primitive Earth Conditions

Abstract

IT has recently been shown that adenine and the purine precursors 4-aminoimidazole-5-carboxamidine and formamidine are formed spontaneously from hydrogen cyanide in water–ammonia systems under conditions assumed to have existed on the primitive Earth1.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Oró, J., Biochem. Biophys. Research Comm., 2, 407 (1960); Oró, J., Nature, 190, 389 (1961); Oró, J., and Kimball, A. P., Arch. Biochem. Biophys (in the press).

    Article  Google Scholar 

  2. Grossman, F., Cristopher, J., and Canavan, G., in Proc. Nat. Sci. Found. Summer Inst. for High School Juniors, 8 (University of Houston, 1960). Oró, J., Fed. Proc., 20, 352 (1961); Proc. Fifth Intern. Cong. Bioehem., Moscow (in the press).

    Google Scholar 

  3. Völker, T., Angew. Chem., 62, 728 (1957); Angew. Chem., 72, 379 (1960).

    Google Scholar 

  4. Lange, O., Ber., 6, 99 (1873); Wippermann, R., Ber., 7, 767 (1874). See also: Long, D. A., and George, W. D., Proc. Chem. Soc., 285 (1960).

    Article  Google Scholar 

  5. Bredereck, H., Schmötzer, G., and Becher, H. S., Ann., 600, 87 (1956).

    CAS  Google Scholar 

  6. Richter, E., Loeffler, J. E., and Taylor, E. C., J. Amer. Chem. Soc., 82, 3144 (1960).

    Article  CAS  Google Scholar 

  7. Taylor, E. C., and Cheng, C. C., Tetrahedron Letters, No. 12, 9 (1959).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ORÓ, J. Mechanism of Synthesis of Adenine from Hydrogen Cyanide under Possible Primitive Earth Conditions. Nature 191, 1193–1194 (1961). https://doi.org/10.1038/1911193a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1911193a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing