Letter | Published:

Controlling Mechanism of the Mechanical Activity of Muscle and that of Blood Coagulation

Naturevolume 191pages8081 (1961) | Download Citation

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Abstract

IT has long been suggested that there exists a relationship between colloidal behaviour of muscle and that of blood, namely, (1) molecular structure of actomyosin and that of fibrinogen (both belong to the k–m–e–f group1), (2) coagulative phenomena both in sarcoplasm and in blood2, and (3) the role of calcium both in contractile activity of muscle and in blood coagulation2. Recently, Heilbrunn2 has suggested that the mechanism of blood coagulation in relation to the mechanism of cellular activity may be significant. The present communication is concerned with the positive results, which were obtained in a model system of the muscle, to demonstrate the close resemblance between the mechanism in mechanical muscular contraction and that in blood coagulation.

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References

  1. 1

    Astbury, W. T., Exp. Cell Res., Supp. 1, 234 (1949).

  2. 2

    Heilbrunn, L. V., The Dynamics of Living Protoplasma (Academic Press, New York, 1956).

  3. 3

    Bendall, J. R., Nature, 181, 1188 (1958).

  4. 4

    Lorand, L., Molnar, J., and Moos, C., Conf. Chemistry of Muscular Contraction (Igaku Shoin, Tokyo, 1957).

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    Kahn, A. J., and Sandow, A., Science, 112, 647 (1950).

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    Huxley, A. F., and Taylor, R. E., J. Physiol., 144, 426 (1958).

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    Fujino, M., Matsushima, T., Muroya, T., Yabu, H., Yamaguchi, S., and Takahashi, M., Nature, 186, 318 (1960).

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    Perry, S. V., and Grey, T. C., Biochem. J., 64, 184 (1956).

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Affiliations

  1. Department of Physiology, Sapporo Medical College, Sapporo, Japan

    • MASAHIRO FUJINO
    • , SABURO YAMAGUCHI
    • , MASA TAKAUJI
    • , KOHKI UCHIDA
    • , MASAHIDE YASUDA
    •  & TATSUAKI MATSUSHIMA

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https://doi.org/10.1038/191080a0

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