Letter | Published:

Controlling Mechanism of the Mechanical Activity of Muscle and that of Blood Coagulation

Naturevolume 191pages8081 (1961) | Download Citation



IT has long been suggested that there exists a relationship between colloidal behaviour of muscle and that of blood, namely, (1) molecular structure of actomyosin and that of fibrinogen (both belong to the k–m–e–f group1), (2) coagulative phenomena both in sarcoplasm and in blood2, and (3) the role of calcium both in contractile activity of muscle and in blood coagulation2. Recently, Heilbrunn2 has suggested that the mechanism of blood coagulation in relation to the mechanism of cellular activity may be significant. The present communication is concerned with the positive results, which were obtained in a model system of the muscle, to demonstrate the close resemblance between the mechanism in mechanical muscular contraction and that in blood coagulation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Astbury, W. T., Exp. Cell Res., Supp. 1, 234 (1949).

  2. 2

    Heilbrunn, L. V., The Dynamics of Living Protoplasma (Academic Press, New York, 1956).

  3. 3

    Bendall, J. R., Nature, 181, 1188 (1958).

  4. 4

    Lorand, L., Molnar, J., and Moos, C., Conf. Chemistry of Muscular Contraction (Igaku Shoin, Tokyo, 1957).

  5. 5

    Kahn, A. J., and Sandow, A., Science, 112, 647 (1950).

  6. 6

    Huxley, A. F., and Taylor, R. E., J. Physiol., 144, 426 (1958).

  7. 7

    Fujino, M., Matsushima, T., Muroya, T., Yabu, H., Yamaguchi, S., and Takahashi, M., Nature, 186, 318 (1960).

  8. 8

    Perry, S. V., and Grey, T. C., Biochem. J., 64, 184 (1956).

Download references

Author information


  1. Department of Physiology, Sapporo Medical College, Sapporo, Japan



  1. Search for MASAHIRO FUJINO in:

  2. Search for SABURO YAMAGUCHI in:

  3. Search for MASA TAKAUJI in:

  4. Search for KOHKI UCHIDA in:

  5. Search for MASAHIDE YASUDA in:

  6. Search for TATSUAKI MATSUSHIMA in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.