Letter | Published:

Haptoglobinuria in Nephrotic Syndromes

Naturevolume 191pages7475 (1961) | Download Citation



As a rule, only traces of haptoglobin can be found, by titrimetric method, in the urine of patients presenting a nephrotic syndrome with considerable proteinuria, as against their serum, which is very rich in α2 globulin and especially in haptoglobin. Actually, it is so only in the case of patients belonging to Smithies's groups 2.1 and 2.2 (ref. 1), for, when the serum belongs to group 1.1, the haptoglobin, of lower molecular weight, filtered through the nephrotic kidney, can reach a concentration of several gm. per litre2,3.

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  1. 1

    Smithies, O., Advances in Protein Chemistry, 14, 65 (1959).

  2. 2

    Jayle, M. F., Vialatte, S., Lagrue, G., and Boussier, G., J. Urol. Med. Chir., 59, 800 (1953).

  3. 3

    Jayle, M. F., and Boussier, G., Bull. Soc. Chim. Biol., 36, 959 (1954).

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  1. Laboratoire de Chimie Biologique, Faculté de Médecine, 45 rue des Saints-Pères, Paris

    • A. MARNAY


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