Alloxan and Hypersensitivity


DURING the course of another investigation, it was found that a diabetogenic dose of alloxan (175–200 mgm./kgm.)1 protects approximately 50 per cent of rats sensitized to horse serum and later injected intravenously with this antigen. The time of death was lengthened in those rats suffering lethal shock. Controls consistently showed 0–10 per cent survivors.

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  1. 1

    Kass, E. H., and Waisbren, B. A., Proc. Soc. Exp. Biol. Med., 60, 303 (1945).

  2. 2

    Ganley, O. H., and Robinson, H. J., Fed. Proc. (March 1959).

  3. 3

    Long, D. A., Miles, A. A., and Perry, W. L. M., Lancet, ii, 902 (1951).

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THOMPSON, G. Alloxan and Hypersensitivity. Nature 190, 822 (1961).

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