Flow of Portal and Hepatic Blood in Normal and Cirrhotic Liver


HEPATIC blood-flow measured by the bromsulphthalein method, the colloidal radiogold method, or other methods is the sum of both portal blood-flow and hepatic arterial blood-flow. As to the relative portal and arterial blood-flow, one-third to one-fourfch of the total hepatic blood-flow was estimated, in animal experiments, to be derived from the hepatic artery under basal conditions1. In some cases with cirrhosis of the liver, in which portocaval shunting operations were performed or portal venous collaterals were accessible, 25–75 per cent or 54 per cent of the total hepatic blood-flow was estimated to be from the hepatic artery2,3. It is desirable to develop a new method which enables the actual measurement of the portal blood-flow and the hepatic arterial blood-flow in normal subjects and cirrhotic patients, but there has been no report except that of Ueda4.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Grindlay, J. H., Herrick, J. F., and Mann, F. C., Amer. J. Physiol., 132, 489 (1941).

  2. 2

    Redeker, A. G., Geller, H. M., and Reynolds, T. B., J. Clin. Invest., 37, 606 (1958).

  3. 3

    Myers, J. D., and Durham, N. C., J. Clin. Invest., 29, 836 (1950).

  4. 4

    Ueda, H., Nihon Naikagakkai Zasshi (J. Japan. Soc. Int. Med.), 42, 591 (1953).

  5. 5

    Bradley, S. E., Ingelfinger, F. J., Bradley, G. P., and Curry, J. J., J. Clin. Invest., 24, 890 (1945).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

NAKAMURA, T., NAKAMURA, S. & KANEKO, T. Flow of Portal and Hepatic Blood in Normal and Cirrhotic Liver. Nature 190, 812–813 (1961). https://doi.org/10.1038/190812b0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.