Quinine Oxidase in Liver and Blood Plasma of Rabbits poisoned with Carbon Tetrachloride


RABBIT liver has been shown to be a rich source of quinine oxidase1,2. The enzyme was also demonstrated in other organs of the rabbit but in much smaller amount (spleen, lungs); none was found in the pancreas, heart, kidney and skeletal muscles2. In normal human blood, quinine oxidase is present in negligible amounts. However, in cases of parenchymatous lesions of the liver, increased amounts could be detected in the blood. Therefore, the determination of this enzyme has been recommended by Baier3 and by Roman and Dulmanis4 as a test for liver damage.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Knox, W. E., J. Biol. Chem., 163, 699 (1946). Lang, K., and Keuer, H., Biochem. Z., 329, 277 (1957).

  2. 2

    Kelsey, F. E., and Oldham, F. K., J. Pharm. Exp. Ther., 79, 77 (1943).

  3. 3

    Baier, H., Klin. Wochenschr., 36, 569 (1958).

  4. 4

    Roman, W., and Dulmanis, A., Lancet, ii, 90 (1959).

  5. 5

    Villela, G. G., Acad. Bras. Cienc. (in the press).

  6. 6

    Baier, H., and Lang, K., Biochem. Z., 329, 381 (1957).

  7. 7

    Villela, G. G., and Mitidieri, E., Nature, 175, 208 (1955). Affonso, O. R., Mitidieri, E., Ribeiro, L. P., and Villela, G. G., Proc. Soc. Exp. Biol. Med., 90, 527 (1955)

  8. 8

    Mitidieri, E., Affonso, O. R., Ribeiro, L. P., and Villela, G. G., Biochim. Biophys. Acta, 17, 587 (1955).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

VILLELA, G. Quinine Oxidase in Liver and Blood Plasma of Rabbits poisoned with Carbon Tetrachloride. Nature 190, 807–808 (1961). https://doi.org/10.1038/190807a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.