Changes of Quantity of Flavin in the Brain after Peripheral Administration of Flavins


IT has been reported from our laboratory1 that flavins produce a change in the electroencephalogram, and that the effect produced by chlorpromazine is partly reversed by flavin adenine dinucleotide. These results suggest that the flavins act on the brain in situ. In an attempt to discover the mechanism of action of flavins, their penetration of the blood–brain barrier was examined by determining the amount of flavin in the rat brain after peripheral injection of flavins.

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NAGATSU-ISHIBASHI, I., NAGATSU, T. & YAGI, K. Changes of Quantity of Flavin in the Brain after Peripheral Administration of Flavins. Nature 190, 728 (1961).

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