Influence of Gamma-Aminobutyric Acid on the Acetylcholine Responses of the denervated Rat-Diaphragm Preparation

Abstract

THE literature on the actions of γ-aminobutyric acid was reviewed comprehensively by Elliott and Jasper in 19591. Several investigators have demonstrated that it and related substances are normal products of brain metabolism, and that it has an important action on brain function as well as on certain peripheral nerve structures2. It is known to reverse the surface-negative post-synaptic potentials of the apical dendrites of the cerebral cortex3 and also blocks transcallosal conduction when injected into the internal carotid artery4. The exact mechanisms by which these effects are produced are still unknown. Hence work on the influence of γ-aminobutyric acid on the acetylcholine responses of the denervated rat's diaphragm was undertaken.

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References

  1. 1

    Elliott, K. A. C., and Jasper, Herbert H., Physiol. Rev., 39, 383 (1959).

  2. 2

    Hobbiger, F., J. Physiol., 144, 349 (1958).

  3. 3

    Iwama, K., and Jasper, H., J. Physiol., 138, 365 (1957).

  4. 4

    Marrazzi, A. S., Hart, E. R., and Rodriguez, J. M., Science, 127, 284 (1958).

  5. 5

    Watson, R. S., Ph.D. (Lond.) thesis, University of London (1951).

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WATSON, R. Influence of Gamma-Aminobutyric Acid on the Acetylcholine Responses of the denervated Rat-Diaphragm Preparation. Nature 190, 724–725 (1961). https://doi.org/10.1038/190724a0

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