Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Karyological Demonstration of Hybridization of Mammalian Cells in vitro

Abstract

IN a recent publication, Barski, Sorieul and Cornefert1 described the formation of cells with a hybrid karyotype in mixed cultures of two mouse cell strains in vitro. The experiments to be described show that this phenomenon is easily reproducible and that it is not limited to a pair of strains of strictly defined karyotypes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Barski, G., Sorieul, S., and Cornefert, F., C.R. Acad Sci., Paris, 251, 1825 (1960).

    CAS  Google Scholar 

  2. Sanford, K. K., Likely, G. D., and Earle, W. R., J. Nat. Cancer Inst., 15, 215 (1954).

    CAS  PubMed  Google Scholar 

  3. Chu, E. H. Y., Sanford, K. K., and Earle, W. R., J. Nat. Cancer Inst., 21, 729 (1958).

    CAS  PubMed  Google Scholar 

  4. Morgan, J. F., Morton, H. J., and Parker, R. C., Proc. Soc. Ext. Biol. Med., 73, 1 (1950).

    Article  CAS  Google Scholar 

  5. Evans, V. J., Bryant, J. C., McQuilkin, W. T., Fioramonti, M. C., Sanford, K. K., Westfall, B. B., and Earle, W. R., Cancer Res., 16, 87 (1956).

    CAS  PubMed  Google Scholar 

  6. Lederberg, J., J. Cell. and Comp. Physiol., 52, Supp. 1, 383 (1958). Schultz, J., Ann. N.Y. Acad. Sci., 71, (6), 994 (1958).

    Article  CAS  Google Scholar 

  7. Hauschka, T. S., J. Cell. and Comp. Physiol., 52, Supp. 1, 197 (1958).

    Article  CAS  Google Scholar 

  8. Jacob, F., and Wollman, E. L., Ann. Inst. Pasteur, 91, 486 (1956).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

SORIEUL, S., EPHRUSSI, B. Karyological Demonstration of Hybridization of Mammalian Cells in vitro . Nature 190, 653–654 (1961). https://doi.org/10.1038/190653b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/190653b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing