Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Incorporation of Thymidine into Deoxyribonucleic Acid by Extracts from Bacteria exposed to Ultra-violet Light

Abstract

ULTRA-VIOLET LIGHT induces a lag in the synthesis of deoxyribonucleic (DNA) acid in Escherichia coli 1. After a dose-dependent incubation interval, the irradiated bacteria will resume synthesis at almost the same rate as prior to exposure. Recently, various investigators2–4 have shown that blockage of ribonucleic acid (RNA) or protein synthesis prevents the recovery of DNA synthesis in bacteria irradiated with ultra-violet light. The capacity of the bacteria to synthesize DNA after exposure is regained with the initial doubling of RNA in the culture5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kelner, A., J. Bacteriol., 65, 252 (1953).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Harold, F. M., and Ziporin, Z. Z., Biochim. Biophys. Acta, 29, 439 (1958).

    Article  CAS  Google Scholar 

  3. Draculic, M., and Errera, M., Biophys. Acta, 31, 459 (1959).

    Article  Google Scholar 

  4. Doudney, C. O., Nature, 184, 189 (1959).

    Article  ADS  CAS  Google Scholar 

  5. Doudney, C. O., and Haas, F. L., Biochim. Biophys. Acta, 40, 375 (1960).

    Article  CAS  Google Scholar 

  6. Billen, D., Nature, 187, 1044 (1960).

    Article  ADS  CAS  Google Scholar 

  7. Kornberg, A., Zimmerman, S. B., Kornberg, S. B., Josse, J., Proc. U.S. Nat. Acad. Sci., 45, 772 (1959).

    Article  ADS  CAS  Google Scholar 

  8. Kornberg, A., Lehman, I. R., and Simms, E. S., Fed. Proc., 15, 291 (1956).

    Google Scholar 

  9. Lehman, I. R., Bessman, M. V., Simms, E. S., and Kornberg, A., J. Biol. Chem., 233, 163 (1958).

    CAS  PubMed  Google Scholar 

  10. Doudney, C. O., Haas, F. L., Proc. U.S. Nat. Acad. Sci., 45, 709 (1959).

    Article  ADS  CAS  Google Scholar 

  11. Billen, D., J. Bacteriol., 80, 86 (1960).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Kanizir, D., and Errera, M., Cold Spring Harbor Symposia Quant. Biol., 21, 19 (1956).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DOUDNEY, C., BILLEN, D. Incorporation of Thymidine into Deoxyribonucleic Acid by Extracts from Bacteria exposed to Ultra-violet Light. Nature 190, 545–546 (1961). https://doi.org/10.1038/190545a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/190545a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing