Effect of 9α-Fluoro-11β-hydroxy-17-methyltestosterone (‘Ultandren’) on the Testis of the Immature Rat

Abstract

‘ULTANDREN’ (Ciba, Ltd.) is known to be an extremely potent oral androgen, approximately ten times as effective as methyltestosterone1. In a preliminary investigation of its effects on the testis of the immature rat comparable doses of ‘Ultandren’ (0.05 mgm.) and methyltestosterone ((0.5 mgm.) dissolved in 0.5 ml. polyethylene glycol were administered daily by mouth for 10 days to litters of rats aged 28–31 days. To a third group of litter mate controls 0.5 ml. of polyethylene glycol was administered daily.

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CLEGG, E. Effect of 9α-Fluoro-11β-hydroxy-17-methyltestosterone (‘Ultandren’) on the Testis of the Immature Rat. Nature 190, 542–543 (1961). https://doi.org/10.1038/190542a0

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