Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide


ALIVISATOS et al. 1,2 reported the formation of histamine dinucleotide, that is, the pyrophosphate of histamine 5′-ribotide and of 5′-adenylic acid, from diphosphopyridine nucleotide (DPN) and histamine, using a soluble, purified preparation of diphosphopyridine nucleotidase3 (DPNase) from bovine spleen. It has been shown that nieotinamide4,5 inhibits the release of histamine by antigen from the lung tissue of a sensitized guinea pig. Nieotinamide is a known inhibitor of DPNase and nieotinamide ribosidase6. These facts suggest the possibility that part of the histamine released during the antigen–antibody reaction is formed from histamine dinucleotide.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Alivisatos, S. G. A., Nature, 181, 271 (1958).

  2. 2

    Alivisatos, S. G. A., Ungar, F., Lukacs, L., and LaMantia, L., J. Biol. Chem., 235, 1742 (1960).

  3. 3

    Alivisatos, S. G. A., and Woolley, D. W. J. Biol. Chem., 219, 823 (1956).

  4. 4

    Yamasaki, H., and Uchida, K., Folia Pharmacol. Japan., 55, 154§ (1959).

  5. 5

    Yamasaki, H., Muraoka, S., and Inoue, M. (unpublished work).

  6. 6

    Grossman, L., and Kaplan, N. O., J. Amer. Chem. Soc., 78, 4175 (1956).

  7. 7

    Kaplan, N. O. in Methods in Enzymology, 11, 660, edit. by Colowick, S. P., and Kaplan, N. O. (Academic Press, New York, 1955).

  8. 8

    Suzuki, T., Iwanaga, S., and Satake, M., J. Pharm. Soc. Jap., 80, 857 (1960).

  9. 9

    Alivisatos, S. G. A., and LaMantia, L., Biochem. and Biophys. Res. Comm., 2, 164 (1960).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MURAOKA, S., INOUE, M. & YAMASAKI, H. Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide. Nature 190, 532–533 (1961). https://doi.org/10.1038/190532a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.