Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide

Abstract

ALIVISATOS et al. 1,2 reported the formation of histamine dinucleotide, that is, the pyrophosphate of histamine 5′-ribotide and of 5′-adenylic acid, from diphosphopyridine nucleotide (DPN) and histamine, using a soluble, purified preparation of diphosphopyridine nucleotidase3 (DPNase) from bovine spleen. It has been shown that nieotinamide4,5 inhibits the release of histamine by antigen from the lung tissue of a sensitized guinea pig. Nieotinamide is a known inhibitor of DPNase and nieotinamide ribosidase6. These facts suggest the possibility that part of the histamine released during the antigen–antibody reaction is formed from histamine dinucleotide.

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References

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MURAOKA, S., INOUE, M. & YAMASAKI, H. Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide. Nature 190, 532–533 (1961). https://doi.org/10.1038/190532a0

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