Abstract
THE first isolation of multiple resistant Shigella was reported by Kitamoto1. This was resistant to four drugs (r 4): streptomycin, tetracycline, chloramphenicol and sulphanilamide. E. coli r 4 was isolated in the epidemic of Sh. flexneri 3a r 4 (refs. 2 and 3). Sh. flexneri 2a r 3 and E. coli r 3 were also isolated in another epidemic, which were resistant to streptomycin, chloramphenicol and sulphanilamide4. Citrobacter r 4 and E. coli r 4 were isolated from a dysenteric patient after treatment with chloramphenicol5.
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MITSUHASHI, S., HARADA, K. & KAMEDA, M. Elimination of Transmissible Drug-resistance by Treatment with Acriflavin. Nature 189, 947 (1961). https://doi.org/10.1038/189947a0
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DOI: https://doi.org/10.1038/189947a0
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