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Optical Rotatory Dispersion of the Thrombin-induced Conversion of Fibrinogen to Fibrin Monomer

Nature volume 189, pages 307–308 (1961)Cite this article

Abstract

CONSIDERABLE evidence has now accumulated suggesting that the thrombin-induced conversion of fibrinogen to fibrin is a reversible triphasic reaction which may be represented thus1: where F is fibrinogen, T is thrombin, ƒ is fibrin monomer, P represents non-protein nitrogenous material consisting primarily of two acidic peptides of molecular weights 1,900 and 2,400, and ƒn represents intermediate polymers where n and m are variable numbers.

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Author information

Author notes

  1. C. M. KAY

    Present address: Department of Biochemistry, University of Alberta, Edmonton, Canada

Authors and Affiliations

  1. The Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana

    C. M. KAY & M. M. MARSH

Authors
  1. C. M. KAY
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  2. M. M. MARSH
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KAY, C., MARSH, M. Optical Rotatory Dispersion of the Thrombin-induced Conversion of Fibrinogen to Fibrin Monomer. Nature 189, 307–308 (1961). https://doi.org/10.1038/189307a0

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