Anti-i : a New Cold Antibody


IN 1956 Wiener and his colleagues1 described an antibody occurring in a case of cold antibody hæmolytic anæmia which they called anti-I. The I antigen has an almost universal distribution, but five examples of i cells were found in testing 22,000 donors. It was considered that the Ii phenotypes arose by the action of two allelomorphic genes I and i, individuals of the phenotype i being ii.


  1. 1

    Wiener, A. S., Unger, L. J., Cohen, L., and Feldman, J., Ann. Intern. Med., 44, 221 (1956).

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  2. 2

    Jenkins, W. J., Marsh, W. L., Noades, J., Tippett, P., Sanger, R., and Race, R. R., Vox Sang., 5, 97 (1960).

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  3. 3

    Tippett, P., Noades, J., Sanger, R., Race, R. R., Sausais, L., Holman, C. A., and Buttimer, J., Vox Sang., 5, 107 (1960).

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MARSH, W., JENKINS, W. Anti-i : a New Cold Antibody. Nature 188, 753 (1960).

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