IN 1956 Wiener and his colleagues1 described an antibody occurring in a case of cold antibody hæmolytic anæmia which they called anti-I. The I antigen has an almost universal distribution, but five examples of i cells were found in testing 22,000 donors. It was considered that the Ii phenotypes arose by the action of two allelomorphic genes I and i, individuals of the phenotype i being ii.
Wiener, A. S., Unger, L. J., Cohen, L., and Feldman, J., Ann. Intern. Med., 44, 221 (1956).
Jenkins, W. J., Marsh, W. L., Noades, J., Tippett, P., Sanger, R., and Race, R. R., Vox Sang., 5, 97 (1960).
Tippett, P., Noades, J., Sanger, R., Race, R. R., Sausais, L., Holman, C. A., and Buttimer, J., Vox Sang., 5, 107 (1960).
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