IN a previous paper, some of us1 have shown that the quaternary ammonium salts of deoxy- and ribonucleic acids are soluble in organic solvents, and that by the addition of a concentrated solution of sodium chloride a precipitate of the sodium salt of the nucleic acids is obtained. It seemed interesting to us to know if the preliminary treatment of a viral ribonucleic acid with a quaternary ammonium salt produces a structural modification which can be demonstrated by the disappearance of the infectivity of the ribonucleic acid.
Aubel-Sadron, G., Beck, G., Ebel, J. P., and Sadron, Ch., Biochim. Biophys. Acta, 42, 542 (1960).
Gierer, A., and Schramm, G., Z. Naturforsch., 11b, 2 (1956).
Guerritore, D., Nature, 181, 419 (1958).
About this article
Cite this article
HIRTH, L., LEBEURIER, G., AUBEL-SADRON, G. et al. Influence of a Quaternary Ammonium Salt on the Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus. Nature 188, 689 (1960). https://doi.org/10.1038/188689a0
Pulse-Labeling Patterns of Microsomal Ribonucleic Acid Extracted with Lauryltrimethylammonium Chloride*
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis (1965)
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects (1964)
Biochimica et Biophysica Acta (1962)