Influence of a Quaternary Ammonium Salt on the Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus

Abstract

IN a previous paper, some of us1 have shown that the quaternary ammonium salts of deoxy- and ribonucleic acids are soluble in organic solvents, and that by the addition of a concentrated solution of sodium chloride a precipitate of the sodium salt of the nucleic acids is obtained. It seemed interesting to us to know if the preliminary treatment of a viral ribonucleic acid with a quaternary ammonium salt produces a structural modification which can be demonstrated by the disappearance of the infectivity of the ribonucleic acid.

References

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HIRTH, L., LEBEURIER, G., AUBEL-SADRON, G. et al. Influence of a Quaternary Ammonium Salt on the Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus. Nature 188, 689 (1960). https://doi.org/10.1038/188689a0

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