Histochemical Demonstration of Some Hydrolytic Enzymes in Atheromatous Aortas


IN connexion with other investigations made in this Department on the pathogenesis of atherosclerosis, our attention was directed to the histochemical changes in early atheromatous plaques. Barrows and Chow1 suggested that a disturbance in the relative concentrations of enzymes within arterial tissue may result from arteriosclerosis. Relatively little is known, however, about the localization of enzymes in atheromatous aortas. Paterson et al. 2 demonstrated alkaline phosphatase in early atheromatous plaques, using Gomori's calcium–cobalt technique. They assumed that the activity was due to vascularization of the intima in early plaques.

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LEVONEN, E., RAEKALLIO, J. & UOTILA, U. Histochemical Demonstration of Some Hydrolytic Enzymes in Atheromatous Aortas. Nature 188, 677–678 (1960). https://doi.org/10.1038/188677b0

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