A New Approach to the Study of Thiamine Deficiency


IT is well known that dietary deficiency of thiamine impairs normal carbohydrate metabolism because of the role of cocarboxylase as coenzyme in the oxidative decarboxylation of pyruvate and α-ketoglutarate1, and the transaldolation and transketolation2 of aldoses and ketoses, which inhibit the liberation of the energy necessary to maintain tissue in its living state. Also, it has been shown that fat has a sparing action on the thiamine3 ; but little is known concerning protein metabolism in this form of avitaminosis.

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    Evans, H. M., and Lepkovsky, S., J. Biol. Chem., 83, 169 (1929). Banerji, G. G., and Yudkin, J., Biochem. J., 36, 530 (1942).

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    Liang, C. C., Ph.D. thesis, University of London (1959), work done in Human Nutrition Research Unit, National Institute for Medical Research, London.

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    D'Abramo, R., Romano, M., and Ruffo, A., Biochem. J., 58, 270 (1958). Ruffo, A., Romano, M., and Adinolfi, A., ibid., 72, 613 (1959).

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LIANG, C. A New Approach to the Study of Thiamine Deficiency. Nature 188, 660–661 (1960). https://doi.org/10.1038/188660b0

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