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Selective Inactivation of the Plasminogen Contaminant in Thrombin

Abstract

THE contamination of preparations of thrombin and fibrinogen with plasminogen, the precursor of the fibrinolytic enzyme, has always presented great difficulties in the measurement of fibrinolytic activity.

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References

  1. Laki, K., Arch. Biochem., 32, 317 (1951).

    Article  CAS  Google Scholar 

  2. Milstone, J. H., J. Gen. Physiol., 25, 679 (1942).

    Article  CAS  Google Scholar 

  3. Ambrus, J. L., Ambrus, C. M., Back, N., Sokal, J. E., and Collins, G. L., Ann. N.Y. Acad. Sci., 68, 97 (1957).

    Article  ADS  CAS  Google Scholar 

  4. Ambrus, C. M., and Markus, G., Amer. J. Physiol., 199, 491 (1960).

    CAS  PubMed  Google Scholar 

  5. Markus, G., and Ambrus, C. M., J. Biol. Chem., 235, 1673 (1960).

    CAS  PubMed  Google Scholar 

  6. Kline, D. L., and Fishman, J. B., Ann. N.Y. Acad. Sci., 68, 25 (1957).

    Article  ADS  CAS  Google Scholar 

  7. Mullertz, S., and Lassen, M., Proc. Soc. Exp. Biol. Med., 82, 265 (1953).

    Google Scholar 

  8. Guest, M. M., Murphy, R. C., Bodnar, S. R., Ware, A. G., and Seegers, W. H., Amer. J. Physiol., 150, 471 (1947).

    CAS  PubMed  Google Scholar 

  9. Astrup, T., Crookston, J., and Macintyre, A., Acta Physiol. Scand., 21, 238 (1950).

    Article  CAS  Google Scholar 

  10. Markus, G., and Karush, F., J. Amer. Chem. Soc., 79, 134 (1957).

    Article  CAS  Google Scholar 

  11. Guest, M. M., and Ware, A. G., Science, 112, 21 (1950).

    Article  ADS  CAS  Google Scholar 

  12. Seegers, W. H., Landaburu, R. H., and Johnson, J. F., Science, 131, 726 (1960).

    Article  ADS  CAS  Google Scholar 

Download references

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MARKUS, G., AMBRUS, C. Selective Inactivation of the Plasminogen Contaminant in Thrombin. Nature 188, 582–583 (1960). https://doi.org/10.1038/188582a0

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