Isocitratase as an Enzymic Indicator of Metabolic Pathways

Abstract

MANY micro-organisms form major quantities of isocitratase only when grown on substrates the catabolism of which ultimately produces acetate, and the provision of even small quantities of intermediates of the tricarboxylic acid cycle represses this formation of the enzyme1–3. This property can be utilized to decide between alternative modes of microbial degradation of growth substrates if one such alternative leads ultimately to the formation of acetate (or acetyl coenzyme A) and the other does not.

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KORNBERG, H. Isocitratase as an Enzymic Indicator of Metabolic Pathways. Nature 188, 488–489 (1960). https://doi.org/10.1038/188488a0

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