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Incorporation of Amino-Acids labelled with Carbon-14 in Nerve Proteins during Activity and Recovery

Abstract

THAT nerve proteins may take an active role during nerve impulse propagation has been proposed in many publications1. In a paper, now in the press, I have suggested that a small fraction of the nerve proteins may split, probably to the level of amino-acids, during nerve activity, and that this process should be fully reversible, appearing as an increased turnover of proteins during impulse conduction or shortly afterwards. The purpose of the present communication is to present evidence in support of these suggestions.

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References

  1. Geiger, A., Yamasaki, S., and Lyons, R., Amer. J. Physiol., 184, 239 (1956). Hyden, H., Symp. Soc. Exp. Biol., 1, 152 (1947). Luxoro, M., Proc. Twenty-first Int. Cong. Physiol. Sci., p. 171. Ungar, G., Ascheim, E., Psychoyos, S., and Romano, D. V., J. Gen. Physiol., 40, 635 (1957).

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  2. Geiger, A., Physiol. Revs., 38, 1 (1958).

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LUXORO, M. Incorporation of Amino-Acids labelled with Carbon-14 in Nerve Proteins during Activity and Recovery. Nature 188, 1119–1120 (1960). https://doi.org/10.1038/1881119a0

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