Letter | Published:

Development of Delayed-type Hypersensitivity in Guinea Pig Embryos

Naturevolume 187pages957959 (1960) | Download Citation



SEVERAL, modalities of the immune response of embryos have been previously investigated. These include : (a) induction of immunological tolerance1; (b) antibody formation2; (c) capacity to reject homografts3. There have been no analogous studies of the capacity of the embryo to develop the delayed type of hypersensitivity to protein antigens.

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  1. 1

    Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).

  2. 2

    Fennestad, K. L., and Borg-Peterson, C., Nature, 180, 1210 (1957). Sterzl, J., Kostka, J., Riha, I., and Mandel, L., Folia Microbiologica, 5, 29 (1960).

  3. 3

    Schinkel, P. G., and Ferguson, K. A., Austral. J. Biol. Sci., 6, 533 (1953).

  4. 4

    Freund, J., J. Immunol., 13, 285 (1927).

  5. 5

    Waksman, B. H., and Matoltsy, M., J. Immunol., 81, 235 (1958).

  6. 6

    Weiss, D. W., J. Exp. Med., 108, 83 (1958).

  7. 7

    Uhr, J. W., Salvin, S., and Pappenheimer, jun., A. M., J. Exp. Med., 105, 11 (1957).

  8. 8

    Gell, P. G. H., and Hinde, I. T., Brit. J. Exp. Path., 32, 516 (1951).

  9. 9

    Ibsen, H. L., J. Exp. Zool., 51, 51 (1928). Draper, R. L., Anat. Rec., 18, 369 (1920).

  10. 10

    Freund, J., J. Immunol., 17, 465 (1929).

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  1. Departments of Microbiology and Medicine, New York University School of Medicine, New York



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