Letter | Published:

Urinary Excretion of β-Amino-isobutyric Acid after Injection of Thymidine labelled with Tritium

Naturevolume 187pages956957 (1960) | Download Citation

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Abstract

β AMINO-isoBUTYRIC acid is a metabolic degradation product of thymine1,2, but its relation to the catabolism of endogenous deoxyribonucleic acid has remained uncertain. In the present c ommunication we present results which elucidate the catabolic fate of that fraction of thymine originating from endogenous deoxyribonucleic acid and reflected in the urinary excretion of β-amino-isobutyric acid.

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References

  1. 1

    Crumpler, H. R., Dent, C. E., Harris, H., and Westall, R. G., Nature 167, 307 (1951).

  2. 2

    Fink, K., Henderson, R. B., and Fink, R. M., Proc. Soc. Exp. Biol. Med., 78, 135 (1951).

  3. 3

    Gerber, G. B., Gerber, G., and Altman, K. I., J. Biol. Chem., 235, 1433 (1960).

  4. 4

    Gerber, G. B., Gerber, G., and Altman, K. I., Clinica Chemica Acta, 5, 607 (1960).

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Affiliations

  1. Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

    • GEORG B. GERBER
    • , GISELA GERBER
    •  & KURT I. ALTMAN

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https://doi.org/10.1038/187956a0

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