Letter | Published:

Antigonadotropic Function of the Pineal Gland and the Oxytocin of the Neurosecretory Hypothalamic System

Naturevolume 187pages950951 (1960) | Download Citation



THE existence of an active substance in the pineal gland capable of inhibiting gonadotropic hormones is supported by most authors who have studied this problem. On the other hand, nothing has been revealed concerning the mechanism which causes this inhibition. The existence of a direct interaction between the pineal-inhibiting factor and gonadotropic hormones does not seem likely. In connexion with investigations carried out on anti-androgenic fractions of bovine pineal gland, one of us claimed that the antigonadotropic function of the pineal gland was exerted at the level of the subcortical centres inhibited by it1.

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  1. 1

    Milcou, S.-M., “Epifiza glandǎ endocrinǎ”, Cong. Nat. Sci. Med., Bucuresti (May, 1957).

  2. 2

    Shibusawa, K., Saito, S., Fukuda, M., Kawai, T., Yamado. K., and Tomizawa, K., Endocrinol. (Japan), 2, 3 (1955).

  3. 3

    Martini, L., Mira, L., Pecile, A., and Saito, S., Acta Endocrinol., Supp. 38 (1958).

  4. 4

    Van Dyke, H. B., Karlis, Adamson, jun., and Stanford, L. Engel, in “Recent Progress in Hormone Research”, 1 (Academic Press. New York, 1955).

  5. 5

    Holton, P., Brit. J. Pharm. Chem., 3, 328 (1948).

  6. 6

    Milcou, S.-M., Pavel, S., and Pterescu, S., Rumanian Med. Rev. (in the press).

  7. 7

    Milin, R., Cong. Nat. Sci. Med. Bucuresti (May, 1957).

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  1. Institute of Endocrinology, Bucharest

    • S.-M. MILCOU
    •  & S. PAVEL


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