Transformation of Resistance to 8-Azaguanine in Diplococcus pneumoniae

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BECAUSE of the importance of purine analogues in the chemotherapy of human neoplastic disease1, several investigations have been made on their mode of action and the mechanism of resistance2 to them in bacterial and animal systems.

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    Burchenal, J. H., in “Current Research in Cancer Chemotherapy”, Report No. 4, National Cancer Institute (U.S.) (1956).

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    Mandel, H. G., Pharmacol. Rev., 11, 743 (1959).

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    Adams, M. H., and Roe, A. S., J. Bact., 49, 401 (1945).

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    Kay, E. R. M., Simmons, N. S., and Dounce, A. L., J. Amer. Chem. Soc., 74, 1724 (1952).

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SIROTNAK, F., LUNT, R. & HUTCHISON, D. Transformation of Resistance to 8-Azaguanine in Diplococcus pneumoniae . Nature 187, 800–801 (1960) doi:10.1038/187800a0

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