Inhibition of Aerobic Glycolysis in Yoshida Ascites Hepatoma by Tartronic Acid

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Abstract

THE inhibition of lactic dehydrogenase should allow a blocking of aerobic glycolysis of neoplastic cells, thus depriving them of a high percentage of adenosine triphosphate without damaging the normal cells which, in conditions of normal functional activity and sufficient oxygen supply, do not need this enzyme1. According to this premise, the action of tartronic acid, which is a lactic dehydrogenase inhibitor2,3, on the growth of Yoshida's ascites hepatoma and Ehrlich's ascites tumour was studied1.

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References

  1. 1

    Fiume, L., Boll. Soc. Ital. Biol. Sper., 34, 434 (1958).

  2. 2

    Quastel, J. H., and Wooldridge, W. R., Biochem. J., 22, 689 (1928).

  3. 3

    Fiume, L., and Reggianini, O., Boll. Soc. Ital. Biol. Sper., 33, 234 (1957).

  4. 4

    Barker, S. B., and Summerson, W. H., J. Biol. Chem., 138, 535 (1941).

  5. 5

    Le Page, G. A., in “Manometric Techniques”, edit. by Umbreit, W. W., Burris, R. H., and Stauffer, J. F., 104 (Burgess, Minneapolis, 1948).

  6. 6

    Bak, B., Ann. Chem., 537, 286 (1939).

  7. 7

    Rieben, W. R., and Hastings, A. B., Helvetica Physiol. et Pharmacol. Acta, 4, C, 52 (1946).

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FIUME, L. Inhibition of Aerobic Glycolysis in Yoshida Ascites Hepatoma by Tartronic Acid. Nature 187, 792–793 (1960) doi:10.1038/187792a0

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