Mechanism of the Physiological Action of Rotenone

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ROTENONE has been widely used as a poison for the extinction of fish populations. Its action was earlier ascribed to a histolysis of the gills1 and a blocking of the circulation2 in the gills. Recently, one of us3 has demonstrated that these effects are secondary changes due to advanced stages of poisoning.

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  1. 1

    Daneel, Rolf, Z. Vergl. Physiol., 18, 524 (1933).

  2. 2

    Hamilton, H. L., Iowa Acad. Sci., 48, 467 (1941).

  3. 3

    Öberg, K. E., Arkiv för Zoologi, 12, No. 25, 383 (1959).

  4. 4

    Schneider, W. C., and Hogeboom, G. H., J. Biol. Chem., 183, 123 (1950).

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LINDAHL, P., ÖBERG, K. Mechanism of the Physiological Action of Rotenone. Nature 187, 784 (1960) doi:10.1038/187784a0

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