Behaviour of Radioactive Griseofulvin in Skin

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Abstract

THE present clinical and laboratory success of griseofulvin in the treatment of superficial fungal infection has prompted investigation into the sites of concentration of this material in an effort to clarify its effects. Preliminary work with spectrophotometry suggested that griseofulvin accumulated, at least for short periods, in the skin. Since this tissue is also the site of the primary infection, I confined my studies to the localization of the agent in that organ, using radioactive griseofulvin the presence of which could be identified by radioassay and autoradiography.

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References

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    Bern, H. A., et al., Acta Anat., 31, 35 (1957).

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    Rudall, K. M., “Adv. in Prot. Chem.”, 7, 253 (1952).

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    Gentles, J. C., Barnes, M. J., and Fantes, K. H., Nature, 183, 256 (1959).

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SCOTT, A. Behaviour of Radioactive Griseofulvin in Skin. Nature 187, 705–707 (1960) doi:10.1038/187705a0

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