Effect of a Primary Tuberculous Infection on the Resistance of Male and Female Mice to Ectromelia

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A TUBERCULOUS infection or vaccination with BCG has been shown to raise the resistance of mice and guinea pigs not only to a challenge with mycobacteria but also to secondary infections caused by other species of bacteria. This latter, non-specific type of immunity has been demonstrated against infection with Brucella abortus 1, Bacillus anthracis and Brucella suis 5, Staphylococcus aureus 2, Pasteurella pestis 3 and Salmonella enteritidis 6. The present work was undertaken to see whether a primary tuberculous infection also increased the resistance of mice to virus infections, using in the first instance ectromelia (mouse pox) as the test virus.

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  1. 1

    Bekierkunst, A., and Sulitzeanu, D., Nature, 182, 883 (1958).

  2. 2

    Dubos, R. J., and Schaedler, R. W., J. Exp. Med., 106, 703 (1957).

  3. 3

    Girard, G., and Grumbach, F., C.R. Soc. Biol., 152, 280 (1958).

  4. 4

    Hart, P. D'Arcy, and Rees, R. J. W., Lancet, ii, 391 (1950).

  5. 5

    Henderson, D. W., Lancaster, M. C., Packman, L., and Peacock, S., Brit. J. Exp. Path., 37, 597 (1956).

  6. 6

    Howard, J. G., Biozzi, G., Halpern, B. N., Stiffel, C., and Mouton, G., Brit. J. Exp. Path., 40, 281 (1959).

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GLEDHILL, A., REES, R. Effect of a Primary Tuberculous Infection on the Resistance of Male and Female Mice to Ectromelia. Nature 187, 703–704 (1960) doi:10.1038/187703b0

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