Recovery of Leukæmogenic Agent from Non-Leukæmic Tissues of Thymectomized Mice

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Abstract

IT has been shown by Gross and others1 that filtrates of leukæmic tissues are leukæmogenic following injection into new-born mice of a low-leukæmic strain, and that total thymectomy prevents the development of lymphocytic leukæmia in inoculated mice2. On the other hand, normal thymuses grafted to inoculated thymectomized hosts as late as 6 months after thymectomy develop lymphocytic neoplasms3. It follows, therefore, that a leukæmogenic agent might be recoverable from the tissues of inoculated mice up to 6 months or more after thymectomy.

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References

  1. 1

    Gross, L., Cancer Res., 18, 371 (1958). Miller, J. F. A. P., Brit. J. Cancer, 14, 83 (1960).

  2. 2

    Gross, L., Proc. Soc. Exp. Biol. and Med., 100, 325 (1959). Levinthal, J. D., Buffett, R. F., and Furth, J., Proc. Soc. Exp. Biol. and Med., 100, 610 (1959). Miller, J. F. A. P., Nature, 183, 1069 (1959).

  3. 3

    Miller, J. F. A. P., Nature, 184, 1809 (1959); Brit. J. Cancer, 14, 93 (1960).

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MILLER, J. Recovery of Leukæmogenic Agent from Non-Leukæmic Tissues of Thymectomized Mice. Nature 187, 703 (1960) doi:10.1038/187703a0

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