Abstract
THE problem of whether oxidative phosphorylation is impaired in diabetes mellitus or not remains obscure. Cutolo and Siliprandi1 and Sacks2 demonstrated a decrease in high-energy bound phosphate content in alloxan-diabetic rat liver. Vester and Stadie3 found diminished oxidative phosphorylation in depancreatized cat liver mitochondria but not in alloxan-diabetic rat liver mitochondria. Parks et al. 4 also failed to find an abnormality in alloxan-diabetic rat liver mitochondria. Goranson and Erulkar5 found uncoupling of oxidative phosphorylation in the heart muscle of alloxan-diabetic rats, but Peterson and his collaborators6 reported that the high-energy bound phosphate content of skeletal muscle was in the normal range.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cutolo, E., and Siliprandi, N., Experientia, 8, 24 (1952).
Sacks, J., Amer. J. Physiol., 172, 93 (1953).
Vester, J. W., and Stadie, W. C., J. Biol. Chem., 227, 669 (1957).
Parks, jun., R. E., Adler, J., and Copenhaver, jun., J. H., J. Biol. Chem., 214, 693 (1955).
Goranson, E. S., and Erulkar, S. D., Arch. Biochem., 24, 40 (1949).
Peterson, R. D., Beatty, C. H., Bocek, R. M., and West, E. S., Amer. J. Physiol., 179, 499 (1954).
Goto, Y., and Ito, I., Tohoku J. Exp. Med., 67, 65 (1957).
Wolff, R., and Paysant, P., Bull. Soc. chim. biol., 33, 1877 (1951).
Ito, I., Tohoku Igaku Z., 56, 592 (1957).
Goto, Y., and Numazawa, Y., Tohoku J. Exp. Med., 68, 57 (1958).
Goto, Y., Ujiie, Y., Takanami, A., Kuwano, A., and Uchiyama, T., Tohoku J. Exp. Med., 69, 131 (1959).
Goto, Y., Ito, I., and Ujiie, Y., Tohoku J. Exp. Med., 68, 51 (1958).
Goto, Y., Ujiie, Y., Takanami, A., Kuwano, A., and Uchiyama, T., Tohoku J. Exp. Med., 69, 137 (1959).
Ujiie, Y., Tohoku Igaku Z., 59, 606 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOTO, Y., ITO, I., KUWANO, A. et al. High-Energy Bound Phosphate and Diabetes Mellitus. Nature 187, 702–703 (1960). https://doi.org/10.1038/187702a0
Issue Date:
DOI: https://doi.org/10.1038/187702a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
