High-Energy Bound Phosphate and Diabetes Mellitus

Article metrics

Abstract

THE problem of whether oxidative phosphorylation is impaired in diabetes mellitus or not remains obscure. Cutolo and Siliprandi1 and Sacks2 demonstrated a decrease in high-energy bound phosphate content in alloxan-diabetic rat liver. Vester and Stadie3 found diminished oxidative phosphorylation in depancreatized cat liver mitochondria but not in alloxan-diabetic rat liver mitochondria. Parks et al. 4 also failed to find an abnormality in alloxan-diabetic rat liver mitochondria. Goranson and Erulkar5 found uncoupling of oxidative phosphorylation in the heart muscle of alloxan-diabetic rats, but Peterson and his collaborators6 reported that the high-energy bound phosphate content of skeletal muscle was in the normal range.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Cutolo, E., and Siliprandi, N., Experientia, 8, 24 (1952).

  2. 2

    Sacks, J., Amer. J. Physiol., 172, 93 (1953).

  3. 3

    Vester, J. W., and Stadie, W. C., J. Biol. Chem., 227, 669 (1957).

  4. 4

    Parks, jun., R. E., Adler, J., and Copenhaver, jun., J. H., J. Biol. Chem., 214, 693 (1955).

  5. 5

    Goranson, E. S., and Erulkar, S. D., Arch. Biochem., 24, 40 (1949).

  6. 6

    Peterson, R. D., Beatty, C. H., Bocek, R. M., and West, E. S., Amer. J. Physiol., 179, 499 (1954).

  7. 7

    Goto, Y., and Ito, I., Tohoku J. Exp. Med., 67, 65 (1957).

  8. 8

    Wolff, R., and Paysant, P., Bull. Soc. chim. biol., 33, 1877 (1951).

  9. 9

    Ito, I., Tohoku Igaku Z., 56, 592 (1957).

  10. 10

    Goto, Y., and Numazawa, Y., Tohoku J. Exp. Med., 68, 57 (1958).

  11. 11

    Goto, Y., Ujiie, Y., Takanami, A., Kuwano, A., and Uchiyama, T., Tohoku J. Exp. Med., 69, 131 (1959).

  12. 12

    Goto, Y., Ito, I., and Ujiie, Y., Tohoku J. Exp. Med., 68, 51 (1958).

  13. 13

    Goto, Y., Ujiie, Y., Takanami, A., Kuwano, A., and Uchiyama, T., Tohoku J. Exp. Med., 69, 137 (1959).

  14. 14

    Ujiie, Y., Tohoku Igaku Z., 59, 606 (1959).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GOTO, Y., ITO, I., KUWANO, A. et al. High-Energy Bound Phosphate and Diabetes Mellitus. Nature 187, 702–703 (1960) doi:10.1038/187702a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.