MNSs Gene Frequencies in English Blood Donors

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Abstract

ESTIMATES of the MNSs gene frequencies in the English population have been based hitherto on the results of tests with anti-M, -N and -S only1,2. Recently, a supply of the very rare anti-s was made available through the kindness of Dr. J. O'Riordan of Dublin3, and a random series of 1,000 Sutton blood donors was tested with all four antisera. The samples were also tested with anti-Mia, -Vw and -Mg. All were negative with the last two antisera, but one donor was found to be Ms/Ns, Mi(a +) Vw −, and a study of her family showed Mi a to be travelling with Ns. The results of the major grouping tests are given in Table 1.

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References

  1. 1

    Race, R. R., and Sanger, R., “Blood Groups in Man”, 51 (1950); 62 (1954); 74 (1958) (Oxford University Press).

  2. 2

    Ikin, E. W., et al., cited by Mourant, A. E., in “The Distribution of the Human Blood Groups”, 358 (Oxford University Press, 1954).

  3. 3

    O'Riordan, J., and Cann, J., Vox Sang., (N.S.), 4, 242 (1959).

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CLEGHORN, T. MNSs Gene Frequencies in English Blood Donors. Nature 187, 701 (1960) doi:10.1038/187701a0

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