Use of Diodone in Renal Studies in Sheep

Article metrics

Abstract

DIODONE (3,5-di-iodo-4-pyridone-N-acetic acid), shown by Elsom et al. 1, Landis et al. 2, and Smith et al. 3 to be an effective agent for the estimation of renal plasma flow and tubular function, has been used extensively in physiological studies. In 1945, Smith et al. 4 showed that p-aminohippuric acid was in some ways superior to diodone for these estimations in man because the urine and plasma blanks are small, and because diodone penetrates human red blood cells whereas p-aminohippuric acid does not. The red cells of dogs are permeable to both reagents.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Elsom, K. A., Bott, P. A., and Shiels, E. H., Amer. J. Physiol., 115, 548 (1936).

  2. 2

    Landis, E. M., Elsom, K. A., Bott, P. A., and Shiels, E. H., J. Clin. Invest., 15, 397 (1936).

  3. 3

    Smith, H. W., Goldring, W., and Chasis, H., J. Clin. Invest., 17, 263 (1938).

  4. 4

    Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford, B., and Graber, M., J. Clin. Invest., 24, 388 (1945).

  5. 5

    Lewin, K., Z. Klin. Med., 42, 371 (1901).

  6. 6

    Alpert, L. K., Bull. Johns Hopkins Hosp., 68, 522 (1941).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

POTTER, B. Use of Diodone in Renal Studies in Sheep. Nature 187, 698 (1960) doi:10.1038/187698a0

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.