Use of Diodone in Renal Studies in Sheep

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DIODONE (3,5-di-iodo-4-pyridone-N-acetic acid), shown by Elsom et al. 1, Landis et al. 2, and Smith et al. 3 to be an effective agent for the estimation of renal plasma flow and tubular function, has been used extensively in physiological studies. In 1945, Smith et al. 4 showed that p-aminohippuric acid was in some ways superior to diodone for these estimations in man because the urine and plasma blanks are small, and because diodone penetrates human red blood cells whereas p-aminohippuric acid does not. The red cells of dogs are permeable to both reagents.

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  1. 1

    Elsom, K. A., Bott, P. A., and Shiels, E. H., Amer. J. Physiol., 115, 548 (1936).

  2. 2

    Landis, E. M., Elsom, K. A., Bott, P. A., and Shiels, E. H., J. Clin. Invest., 15, 397 (1936).

  3. 3

    Smith, H. W., Goldring, W., and Chasis, H., J. Clin. Invest., 17, 263 (1938).

  4. 4

    Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford, B., and Graber, M., J. Clin. Invest., 24, 388 (1945).

  5. 5

    Lewin, K., Z. Klin. Med., 42, 371 (1901).

  6. 6

    Alpert, L. K., Bull. Johns Hopkins Hosp., 68, 522 (1941).

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POTTER, B. Use of Diodone in Renal Studies in Sheep. Nature 187, 698 (1960) doi:10.1038/187698a0

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